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TITLE Molecular and Cellular Transitions from ES Cells to Mature Functioning Human Neurons ABSTRACT Human embryonic stem cells (hESCs) are pluripotent entities, capable of generating a whole-body spectrum of distinct cell types. We have developmental procedures for inducing hESCs to develop into pure populations of human neural stem cells (hNS), a step required for generating authentic mature human neurons. Several protocols have currently been developed to differentiate hESCs to what appear to be differentiated dopaminergic neurons (important in Parkinson
PI Fred Gage INSTITUTE The Salk Institute for Biological Studies STATE California AMOUNT $2,879,210.00 AWARD DATE 2007 March GRANT TYPE Comprehensive