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TITLE A CIRM Disease Team for the Repair of Traumatically Injured and Arthritic Cartilage ABSTRACT Arthritis is a disabling condition that afflicts 6 million Californians, costing our state nearly $32 billion annually for health care and lost wages. Given the growth of an aging population encouraged to maintain an active lifestyle due to the overall health benefits, the impact of arthritis is expected to increase significantly. For example, the Center for Disease Control projects that 60 million people nationwide will have arthritis by 2020. The goal of this Disease Team Proposal is to plan an accelerated translation of stem cell therapies for cartilage repair that will provide an early intervention to prevent and treat arthritis. The proposed cartilage regeneration program builds upon the institutional applicant's world-recognized leadership in stem cell and skeletal biology, and the clinical expertise of the orthopaedic surgery. In addition, strong partnerships with California industry will facilitate successful implementation of clinically beneficial strategies. The team leader is the director of both an industry-collaborative center and an orthopaedic biomechanics laboratory, and a pioneer of new protocols that direct stem cells to make cartilage. Our multidisciplinary team members at Bay Area research institutions have well-established interactions that serve as the foundation of our program to propel translation of stem cell therapy. The majority of team members are affiliated with a center focused on cartilage repair and regeneration which fosters such collaborations. In fact, we are already executing pre-clinical studies to assess the potential of stem cells to repair cartilage, and human clinical trials using a patient's own cartilage cells to treat cartilage erosions. In addition to advancing novel treatments, our team includes international leaders in the development of novel imaging technologies to track implanted stem cells and cartilage repair. These non-invasive imaging techniques will be critical for assessing early success in large animal studies and human clinical trials. Successful completion of this Disease Team Award will result in the development of a non-invasive imaging technology for early detection and localization of cartilage erosions, and a minimally invasive stem cell-based treatment that can be used to heal cartilage and prevent arthritis progression. Such a treatment option does not currently exist. This CIRM Disease Team Planning Grant will assemble experts in all areas necessary for realizing clinical translation, and define milestones to coordinate, motivate, and accelerate development of a stem cell-based therapy for cartilage regeneration.
PI Jeffrey Lotz INSTITUTE University of California, San Francisco STATE California AMOUNT $55,000.00 AWARD DATE 2008 June GRANT TYPE Disease Team Planning